Synthesis of the matriglycan hexasaccharide, -3Xylα1-3GlcAβ1-trimer and its interaction with laminin-Reference-Cited by-同舟云学术

Synthesis of the matriglycan hexasaccharide, -3Xylα1-3GlcAβ1-trimer and its interaction with laminin

Published:2022 Issue:43 Volume:20 Page:8489-8500
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tamura Takahiro¹^ORCID,Omura Yuka²,Kotera Kota²^ORCID,Ito Ryota³^ORCID,Ohno Shiho³^ORCID,Manabe Noriyoshi³^ORCID,Yamaguchi Yoshiki³^ORCID,Tamura Jun-ichi¹²^ORCID

Affiliation:

1. The United Graduate School of Agricultural Sciences, Tottori University, Tottori, 680-8553 Japan

2. Department of Agricultural, life and Environmental Sciences, Faculty of Agriculture, Tottori University, Tottori, 680-8553 Japan

3. Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558 Japan

Abstract

Matriglycan hexasaccharide (-3Xylα1-3GlcAβ1)3-O(C2H4O)3CH2CCH and the biotin conjugate was synthesized. The hexasaccharide showed good interaction with laminin-G-like domains 4 and 5 of laminin-α2 using saturation transfer difference-NMR and bio-layer interferometry.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01388F

Reference20 articles.

1. Mechanistic aspects of the formation of α-dystroglycan and therapeutic research for the treatment of α-dystroglycanopathy: A review

2. Glycosylation with ribitol-phosphate in mammals: New insights into the O -mannosyl glycan

3. Muscular Dystrophy with Ribitol-Phosphate Deficiency: A Novel Post-Translational Mechanism in Dystroglycanopathy

4. Dystroglycanopathy: From Elucidation of Molecular and Pathological Mechanisms to Development of Treatment Methods

5. Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE

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