A novel signal amplification strategy for highly specific and nonenzymatic isothermal electrochemiluminescence detection of tumour markers-Reference-Cited by-同舟云学术

A novel signal amplification strategy for highly specific and nonenzymatic isothermal electrochemiluminescence detection of tumour markers

Published:2020 Issue:7 Volume:12 Page:938-942
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Liu Yan¹²³⁴⁵^ORCID,Guo Xin⁶⁷³⁴⁵,Fan Zhijin⁸⁹¹⁰¹¹⁵^ORCID,Liao Yuhui⁸⁹¹⁰¹¹⁵^ORCID,Yu Ying¹²³⁴⁵,Guo Manli¹²³⁴⁵,Cao Yujuan¹²³⁴⁵^ORCID,Zhu Debin¹²³⁴⁵

Affiliation:

1. Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine

2. School of Chemistry

3. South China Normal University

4. Guangzhou 510006

5. China

6. Centre for Optical and Electromagnetic Research

7. South China Academy of Advanced Optoelectronics

8. Program of Infection and Immunity

9. The Fifth Affiliated Hospital of Sun Yat-sen University

10. Zhongshan School of Medicine

11. Sun Yat-sen University

Abstract

A signal amplification strategy for highly specific and nonenzymatic isothermal electrochemiluminescence detection of microRNA was developed. The limit of detection was as low as 4 fmol, which was superior to that for the reported linear DNA method.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/C9AY02310K

Reference13 articles.

1. MicroRNAs and Cancer: Short RNAs Go a Long Way

2. MicroRNA detection by an amplification-free biosensor based on controllable solid-state electrochemiluminescence quenched by charge transfer

3. MicroRNA-triggered, cascaded and catalytic self-assembly of functional “DNAzyme ferris wheel” nanostructures for highly sensitive colorimetric detection of cancer cells

4. MicroRNA: Function, Detection, and Bioanalysis

5. Ultrasensitive Detection of microRNAs by Exponential Isothermal Amplification

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