On-demand radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on an electrowetting-on-dielectric microfluidic chip for 18F-labeling of protein-Reference-Cited by-同舟云学术

On-demand radiosynthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) on an electrowetting-on-dielectric microfluidic chip for 18F-labeling of protein

Published:2019 Issue:55 Volume:9 Page:32175-32183
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kim Hee-Kwon¹²³⁴⁵^ORCID,Javed Muhammad Rashed¹²³⁴⁵,Chen Supin⁶⁷⁸⁹,Zettlitz Kirstin A.¹²³⁴⁵^ORCID,Collins Jeffrey¹²³⁴⁵,Wu Anna M.¹²³⁴⁵,Kim Chang-Jin “C. J.”¹⁰²³⁴¹¹^ORCID,Michael van Dam R.¹²³⁴⁵^ORCID,Keng Pei Yuin¹²³⁴⁵^ORCID

Affiliation:

1. Department of Molecular and Medical Pharmacology

2. University of California, Los Angeles

3. Los Angeles

4. USA

5. Crump Institute for Molecular Imaging

6. Department of Materials Science and Engineering

7. National Tsing Hua University

8. Hsinchu

9. Taiwan

10. Bioengineering Department

11. Mechanical and Aerospace Engineering Department

Abstract

An all-electronic, droplet-based batch microfluidic device, operated using the electrowetting on dielectric (EWOD) mechanism was developed for on-demand synthesis of acommonly used ¹⁸F-prosthetic group for biomolecule labeling.

Funder

David Geffen School of Medicine, University of California, Los Angeles

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA06158D

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