Synthesis and antitumor effects of novel benzyl naphthyl sulfoxide/sulfone derivatives derived from Rigosertib-Reference-Cited by-同舟云学术

Synthesis and antitumor effects of novel benzyl naphthyl sulfoxide/sulfone derivatives derived from Rigosertib

Published:2021 Issue:59 Volume:11 Page:37462-37471
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tang Lin¹^ORCID,Chen Tingting¹,Yang Hongpeng¹²,Wen Xiaoxue¹,Sun Yunbo¹,Liu Shuchen¹,Peng Tao¹,Zhang Shouguo¹,Wang Lin¹²^ORCID

Affiliation:

1. Beijing Institute of Radiation Medicine, Beijing 100850, P. R. China

2. Faculty of Environment & Life, Beijing University of Technology, Beijing 100124, P. R. China

Abstract

In this work, a series of novel benzyl naphthyl sulfoxides/sulfones derived from Rigosertib were designed and synthesized as potential antitumor agents.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA05226H

Reference28 articles.

1. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome

2. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent

3. Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells

4. Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

5. Discovery of a Clinical Stage Multi-Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure–Activity Relationship, and Biological Activity

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