The design, synthesis, in vitro biological evaluation and molecular modeling of novel benzenesulfonate derivatives bearing chalcone moieties as potent anti-microtubulin polymerization agents-Reference-Cited by-同舟云学术

The design, synthesis, in vitro biological evaluation and molecular modeling of novel benzenesulfonate derivatives bearing chalcone moieties as potent anti-microtubulin polymerization agents

Published:2015 Issue:30 Volume:5 Page:23767-23777
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shen Yu-Ning¹²³⁴,Lin Lin¹²³⁴,Qiu Han-Yue¹²³⁴,Zou Wen-Yan¹²³⁴,Qian Yong¹²³⁴,Zhu Hai-Liang¹²³⁴

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology

2. Nanjing University

3. Nanjing 210093

4. China

Abstract

Binding mode of compound 6b with microtubule (PDB code: 1SA0). (a) 2D diagram of the interaction between compound 6b and amino acid residues of colchicine site nearby. (b) 3D diagram of compound 6b inserted in microtubulin colchicine site.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA12108B

Reference23 articles.

1. Microtubule-binding agents: a dynamic field of cancer therapeutics

2. A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

3. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

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