Rapid structural discrimination of IgG antibodies by multicharge-state collision-induced unfolding-Reference-Cited by-同舟云学术

Rapid structural discrimination of IgG antibodies by multicharge-state collision-induced unfolding

Published:2021 Issue:58 Volume:11 Page:36502-36510
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yin Zhibin¹,Du Mingyi¹²,Chen Dong¹²,Zhang Wenyang¹,Huang Wenjie¹,Wu Xinzhou²^ORCID,Yan Shijuan¹^ORCID

Affiliation:

1. Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China

2. State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Key Laboratory of Natural Pesticide and Chemical Biology of the Ministry of Education, South China Agricultural University, Guangzhou, 510642, China

Abstract

A simplified multicharge-state collision-induced unfolding (CIU) method was proposed for rapid differentiation of IgG isotypes that differ in terms of the numbers and patterns of disulfide bonds.

Funder

National Natural Science Foundation of China

Special Fund for Scientific Innovation Strategy-Construction of High-level Academy of Agriculture Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA06486J

Reference48 articles.

1. Neutralizing monoclonal antibodies for treatment of COVID-19

2. Next generation antibody drugs: pursuit of the 'high-hanging fruit'

3. The clinical development of antibody–drug conjugates — lessons from leukaemia

4. Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

5. Strategies and challenges for the next generation of antibody–drug conjugates

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