Modulation of acetylcholinesterase activity using molecularly imprinted polymer nanoparticles

Author:

Piletsky Sergey A.1,Bedwell Thomas S.12,Paoletti Rachele1,Karim Kal1,Canfarotta Francesco2,Norman Rachel3,Jones Donald J. L.34,Turner Nicholas W.5ORCID,Piletska Elena V.1

Affiliation:

1. Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK

2. MIP Diagnostics Ltd, Colworth Science Park, Sharnbrook, MK44 1LQ, UK

3. Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK

4. Department of Cancer Studies, University of Leicester, Leicester, LE2 7LX, UK

5. School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK

Abstract

Epitope mapping and nanoMIP development lead to materials that modulate enzyme activity and promote reactivation after antagonist exposure.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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