Base pairing involving artificial bases in vitro and in vivo-Reference-Cited by-同舟云学术

Base pairing involving artificial bases in vitro and in vivo

Published:2016 Issue:2 Volume:7 Page:995-1010
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bande Omprakash¹²³⁴⁵,Braddick Darren⁶⁷⁸⁹,Agnello Stefano¹²³⁴⁵,Jang Miyeon¹²³⁴⁵,Pezo Valérie⁶⁷⁸⁹,Schepers Guy¹²³⁴⁵,Rozenski Jef¹²³⁴⁵,Lescrinier Eveline¹²³⁴⁵,Marlière Philippe⁶⁷⁸⁹,Herdewijn Piet⁶⁷⁸⁹¹

Affiliation:

1. Medicinal Chemistry

2. Rega Institute for Medical Research

3. KU Leuven

4. 3000 Leuven

5. Belgium

6. iSSB – CNRS FRE3561

7. University of Evry-Val-d'Essonne

8. F-91030 Évry Cedex

9. France

Abstract

Herein we report the synthesis, base pairing properties and in vivo transliteration of N⁸-glycosylated 8-aza-deoxyguanosine and 8-aza-9-deaza-deoxyguanosine nucleotides with 8-amino-deoxyinosine, 1-N-methyl-8-amino-deoxyinosine and 7,8-dihydro-8-oxo-deoxy-inosine/adenosine/guanosine as pairing partners.

Funder

European Research Council

Fonds Wetenschappelijk Onderzoek

KU Leuven

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03474D

Reference53 articles.

1. Understanding Nucleic Acids Using Synthetic Chemistry