Encapsulation of 4-oxo-N-(4-hydroxyphenyl) retinamide in human serum albumin nanoparticles promotes EZH2 degradation in preclinical neuroblastoma models

Author:

Mrunalini Boddu1ORCID,Dev Atul1,Kushwaha Avinash Chandra1,Sardoiwala Mohammed Nadim1,Karmakar Surajit1ORCID

Affiliation:

1. Institute of Nano Science and Technology, Knowledge City, Sector 81, Mohali 140306, India

Abstract

Schematic represents 4O4HPR loaded HSANPs directing the proteasomal degradation of the polycomb group of the protein, EZH2, by triggering oxidative stress and PKC-δ activation, leading to the killing of neuroblastoma cancer cells.

Funder

Department of Science and Technology, Ministry of Science and Technology

Council of Scientific and Industrial Research, India

Department of Biotechnology, Ministry of Science and Technology, India

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

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