Mechanistic studies of a “Declick” reaction

Author:

Meadows Margaret K.1234,Sun Xiaolong56789ORCID,Kolesnichenko Igor V.1011124ORCID,Hinson Caroline M.113144ORCID,Johnson Kenneth A.151617144,Anslyn Eric V.113144ORCID

Affiliation:

1. Department of Chemistry

2. Mercer University

3. Macon

4. USA

5. The Key Laboratory of Biomedical Information Engineering of Ministry of Education

6. School of Life Science and Technology

7. Xi'an Jiaotong University

8. Xi'an 710049

9. P. R. China

10. Photovoltaics & Materials Technology Department

11. Sandia National Laboratories

12. Albuquerque

13. University of Texas at Austin

14. Austin

15. Institute for Cellular and Molecular Biology

16. Department of Molecular Biosciences

17. University of Texas

Abstract

Detailed kinetic analysis reveals a complex multi-step mechanism for an amine-thiol “declick” reaction.

Funder

National Science Foundation

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference17 articles.

1. Click and chemically triggered declick reactions through reversible amine and thiol coupling via a conjugate acceptor

2. An Auto‐Inductive Cascade for the Optical Sensing of Thiols in Aqueous Media: Application in the Detection of a VX Nerve Agent Mimic

3. E. V. Anslyn and D. A.Dougherty , Modern Physical Organic Chemistry , University Science Books , 2006 , pp. 355–487

4. F. A. Carey and R. J.Sundberg , Advanced Organic Chemistry: Part A: Structure and Mechanisms , Springer Science & Business Media , 2007 , pp. 253–388

5. A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics

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