Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(i) complex

Author:

He Liang12345ORCID,Pan Zheng-Yin56784,Qin Wei-Wei1234,Li Yi910111213,Tan Cai-Ping56784,Mao Zong-Wan12345ORCID

Affiliation:

1. College of Materials and Energy

2. South China Agricultural University

3. Guangzhou 510642

4. China

5. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry

6. School of Chemistry

7. Sun Yat-sen University

8. Guangzhou 510275

9. Key Laboratory of Theoretical Organic Chemistry and Function Molecule

10. Ministry of Education

11. School of Chemistry and Chemical Engineering

12. Hunan University of Science and Technology

13. Xiangtan 411201

Abstract

A Re(i) complex induces autophagy, which is arrested at the lysosomal stage due to lysosomal dysfunction, and inhibits tumor growth in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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