The effect of vitamin C and iron on dopamine-mediated free radical generation: implications to Parkinson's disease-Reference-Cited by-同舟云学术

The effect of vitamin C and iron on dopamine-mediated free radical generation: implications to Parkinson's disease

Published:2018 Issue:12 Volume:47 Page:4059-4069
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sun Yingying¹²³⁴,Pham An Ninh¹²³⁴,Waite T. David¹²³⁴^ORCID

Affiliation:

1. School of Civil and Environmental Engineering

2. The University of New South Wales

3. Sydney

4. Australia

Abstract

While the application of Asc alone may aggravate the progression of PD in view of the possible peroxidation of Asc bound Fe(ii), a combination therapy of Asc and strong clinically appropriate iron chelator would appear to be a promising direction for the treatment of PD as a result of the enhanced iron chelation and attenuation in oxidative stress and toxicity induced by DA derived quinones.

Funder

China Scholarship Council

University of New South Wales

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/DT/C7DT04373B

Reference65 articles.

1. Complexity of dopamine metabolism

2. Clinical observations on the rate of progression of idiopathic parkinsonism