(E)-Selective Friedel–Crafts acylation of alkynes to β-chlorovinyl ketones: defying isomerizations in batch reactions by flow chemistry approaches-Reference-Cited by-同舟云学术

(E)-Selective Friedel–Crafts acylation of alkynes to β-chlorovinyl ketones: defying isomerizations in batch reactions by flow chemistry approaches

Published:2019 Issue:11 Volume:6 Page:1868-1872
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Koo Hyungmo¹²³⁴⁵^ORCID,Kim Hun Young¹²³⁴⁵^ORCID,Oh Kyungsoo¹²³⁴⁵^ORCID

Affiliation:

1. Center for Metareceptome Research

2. College of Pharmacy

3. Chung-Ang University

4. Seoul 06974

5. Republic of Korea

Abstract

Flow chemistry approaches provide a fast, clean, and stereoselective synthetic route to (E)-β-chlorovinyl ketones, free from inherent (E) → (Z) isomerization.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00217K

Reference34 articles.

1. β-Chlorovinyl Ketones

2. Stereoselective Synthesis of β-Chlorovinyl Ketones and Arenes by the Catalytic Addition of Acid Chlorides to Alkynes

3. A Facile Access to 4-Substituted-2-naphthols via a Tandem Friedel–Crafts Reaction: A β-Chlorovinyl Ketone Pathway

4. Unified Approach to (Thio)chromenones via One-Pot Friedel–Crafts Acylation/Cyclization: Distinctive Mechanistic Pathways of β-Chlorovinyl Ketones

5. A One-Pot Synthesis of Pyranone and Pyrrole Derivatives from β-Chlorovinyl Ketones via Direct Conjugate Addition Approach

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