Dendrimer–tesaglitazar conjugate induces a phenotype shift of microglia and enhances β-amyloid phagocytosis-Reference-Cited by-同舟云学术

Dendrimer–tesaglitazar conjugate induces a phenotype shift of microglia and enhances β-amyloid phagocytosis

Published:2021 Issue:2 Volume:13 Page:939-952
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

DeRidder Louis¹²³⁴⁵^ORCID,Sharma Anjali¹²³⁴⁵^ORCID,Liaw Kevin¹²³⁴⁵,Sharma Rishi¹²³⁴⁵^ORCID,John John¹²³⁴⁵,Kannan Sujatha⁶⁷⁴⁵⁸,Kannan Rangaramanujam M.¹²³⁴⁵^ORCID

Affiliation:

1. Center for Nanomedicine

2. Department of Ophthalmology

3. Wilmer Eye Institute Johns Hopkins University School of Medicine

4. Baltimore

5. USA

6. Department of Anesthesiology and Critical Care Medicine

7. Johns Hopkins University School of Medicine

8. Hugo W. Moser Research Institute at Kennedy Krieger

Abstract

Switching microglia from a disease exacerbating, ‘pro-inflammatory’ state into a neuroprotective, ‘anti-inflammatory’ phenotype is a promising strategy for addressing multiple neurodegenerative diseases.

Funder

National Institute of Child Health and Human Development

Johns Hopkins University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR05958G

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