Role of heterocycles in inhibition of VEGFR-2 – a recent update (2019

Role of heterocycles in inhibition of VEGFR-2 – a recent update (2019–2022)

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Dorababu Atukuri¹^ORCID

Affiliation:

1. SRMPP Government First Grade College, Huvinahadagali, 583219, India

Abstract

The review describes anti-VEGFR-2 activity of heterocycles including quinazoles, pyrimidines, isatin and azoles considering SAR for a given set of derivatives. Compounds with potent activity were emphasized with description of structural features.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00506B

Reference95 articles.

1. Structure and function of VEGF receptors

2. Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition

3. Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

4. Clinical Implications of Circulating Angiogenic Factors in Cancer Patients

5. Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase

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