DePEGylation strategies to increase cancer nanomedicine efficacy-Reference-Cited by-同舟云学术

DePEGylation strategies to increase cancer nanomedicine efficacy

Published:2019 Issue:2 Volume:4 Page:378-387
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Kong Li¹²³⁴,Campbell Frederick¹²³⁴,Kros Alexander¹²³⁴^ORCID

Affiliation:

1. Leiden Institute of Chemistry – Supramolecular and Biomaterial Chemistry

2. Leiden University

3. 2333CC Leiden

4. The Netherlands

Abstract

PEGylation of nanoparticles prolongs circulation lifetimes and maximizes nanoparticle accumulation in target tumors. However, PEGylation comes at the cost of reduced cellular uptake of nanoparticles and concomitant drug delivery. This review discusses the various stimuli-responsive dePEGylation strategies that have been employed to overcome this “PEG dilemma”.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NH/C8NH00417J

Reference179 articles.

1. Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments

2. Targeted drug delivery to tumors: Myths, reality and possibility

3. Strategies and challenges for the next generation of antibody–drug conjugates

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