A click-flipped enzyme substrate boosts the performance of the diagnostic screening for Hunter syndrome-Reference-Cited by-同舟云学术

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A click-flipped enzyme substrate boosts the performance of the diagnostic screening for Hunter syndrome

Published:2020 Issue:47 Volume:11 Page:12671-12676
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Schwarz Markus¹²³⁴⁵,Skrinjar Philipp¹²³⁴,Fink Michael J.⁶⁷⁸⁹^ORCID,Kronister Stefan¹²³⁴^ORCID,Mechtler Thomas⁵¹⁰⁴,Koukos Panagiotis I.¹¹¹²¹³¹⁴¹⁵,Bonvin Alexandre M. J. J.¹¹¹²¹³¹⁴¹⁵,Kasper David C.⁵¹⁰⁴,Mikula Hannes¹²³⁴^ORCID

Affiliation:

1. Institute of Applied Synthetic Chemistry

2. TU Wien

3. 1060 Vienna

4. Austria

5. ARCHIMED Life Science GmbH

6. Department of Chemistry and Chemical Biology

7. Harvard University

8. Cambridge

9. USA

10. 1110 Vienna

11. Bijvoet Centre for Biomolecular Research

12. Faculty of Science – Chemistry

13. Utrecht University

14. 3584CH Utrecht

15. The Netherlands

Abstract

Click-triggered flip of the conformation of a sulfated iduronyl azide afforded a superior enzyme substrate to screen for Hunter syndrome.

Funder

Österreichische Forschungsförderungsgesellschaft

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC04696E

Reference41 articles.

1. The cell biology of lysosomal storage disorders

2. Mucopolysaccharidosis Type II: One Hundred Years of Research, Diagnosis, and Treatment

3. Identification of iduronate sulfatase gene alterations in 70 unrelated Hunter patients

4. Multidisciplinary Management of Hunter Syndrome

5. Recognition and Diagnosis of Mucopolysaccharidosis II (Hunter Syndrome)

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. On the Mechanism of the Lysosomal Enzyme Iduronate‐2‐sulfatase. A Multiscale Approach;ChemCatChem;2024-04-26

2. Thiol‐Functionalized Cellulose Wrapped Copperoxide as a Green Nano Catalyst for Regiospecific Azide‐Alkyne Cycloaddition Reaction: Application in Rufinamide Synthesis;Asian Journal of Organic Chemistry;2021-11-23

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