Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket-Reference-Cited by-同舟云学术

Pharmacomodulation of a ligand targeting the HBV capsid hydrophobic pocket

Published:2022 Issue:30 Volume:13 Page:8840-8847
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Briday Mathilde¹,Hallé François²,Lecoq Lauriane¹,Radix Sylvie²,Martin Juliette¹,Montserret Roland¹,Dujardin Marie¹,Fogeron Marie-Laure¹,Nassal Michael³^ORCID,Meier Beat H.⁴,Lomberget Thierry²^ORCID,Böckmann Anja¹^ORCID

Affiliation:

1. Molecular Microbiology and Structural Biochemistry (MMSB) UMR 5086 CNRS/Université de Lyon, Labex Ecofect, 7 Passage du Vercors, 69367 Lyon, France

2. Université de Lyon, Université Lyon 1, CNRS UMR 5246 Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Faculté de Pharmacie-ISPB, 8 Avenue Rockefeller, FR-69373 Lyon Cedex 08, France

3. Department of Medicine II/Molecular Biology, University Hospital Freiburg, Medical Center, University of Freiburg, Freiburg 79106, Germany

4. Physical Chemistry, ETH Zürich, 8093 Zürich, Switzerland

Abstract

Small-molecule binding to the Hepatitis B virus core protein hydrophobic pocket, a possible strategy for targeting viral particle assembly.

Funder

Centre National de la Recherche Scientifique

Agence Nationale de la Recherche

Agence Nationale de Recherches sur le Sida et les Hepatites Virales

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry