trans-Platinum(iv) pro-drugs that exhibit unusual resistance to reduction by endogenous reductants and blood serum but are rapidly activated inside cells:1H NMR and XANES spectroscopy study-Reference-Cited by-同舟云学术

trans-Platinum(iv) pro-drugs that exhibit unusual resistance to reduction by endogenous reductants and blood serum but are rapidly activated inside cells:1H NMR and XANES spectroscopy study

Published:2020 Issue:23 Volume:49 Page:7722-7736
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Chen Catherine K. J.¹²³,Kappen Peter⁴⁵⁶³,Gibson Dan⁷⁸⁹¹⁰^ORCID,Hambley Trevor W.¹²³^ORCID

Affiliation:

1. School of Chemistry

2. The University of Sydney

3. Australia

4. Australian Synchrotron

5. ANSTO

6. Melbourne

7. Institute of Drug Research

8. School of Pharmacy

9. The Hebrew University of Jerusalem

10. Israel

Abstract

All-trans diammine platinum complexes with four carboxylate donors are stable in the presence ofl-ascorbate and blood serum, but are reduced rapidly in whole blood and in cancer cells.

Funder

Australian Nuclear Science and Technology Organisation

Israel Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01622E

Reference35 articles.

1. The Inhibition of Growth or Cell Division in Escherichia coli by Different Ionic Species of Platinum(IV) Complexes

2. Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes