Design, synthesis, and anti-hepatocellular carcinoma of thiopyrimidine/chalcone hybrids as dual STAT3/STAT5 inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, and anti-hepatocellular carcinoma of thiopyrimidine/chalcone hybrids as dual STAT3/STAT5 inhibitors

Published:2023 Issue:10 Volume:14 Page:1981-1991
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Altwaijry Najla¹^ORCID,Sabour Rehab²,Ibrahim Mona H.²^ORCID,Al kamaly Omkulthom¹^ORCID,Abdullah Omeima³^ORCID,Harras Marwa F.²^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia

2. Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

3. Pharmaceutical Chemistry Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

Abstract

New thiopyrimidine/chalcone hybrids were synthesized for hepatocellular carcinoma treatment. Compound 5h was the most active one. Additionally, it displayed STAT3/STAT5 dual inhibitory action which was confirmed by western blot analysis.

Funder

Princess Nourah Bint Abdulrahman University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00300K

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