Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels-Reference-Cited by-同舟云学术

Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels

Published:2023 Issue:47 Volume:14 Page:13743-13754
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Rochet Léa N. C.¹,Bahou Calise¹,Wojciechowski Jonathan P.²^ORCID,Koutsopetras Ilias³^ORCID,Britton Phyllida¹,Spears Richard J.¹^ORCID,Thanasi Ioanna A.¹,Shao Baihao²,Zhong Lisha²,Bučar Dejan-Krešimir¹^ORCID,Aliev Abil E.¹,Porter Michael J.¹^ORCID,Stevens Molly M.²^ORCID,Baker James R.¹^ORCID,Chudasama Vijay¹^ORCID

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK

2. Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK

3. Bio-Functional Chemistry (UMR 7199), Institut du Médicament de Strasbourg, University of Strasbourg, 74 Route du Rhin, 67400 Illkirch-Graffenstaden, France

Abstract

Substituted pyridazinediones (PDs) enable reversible and tuneable cysteine modification with exemplification on peptides, proteins and hydrogels.

Funder

Leverhulme Trust

Engineering and Physical Sciences Research Council

UK Regenerative Medicine Platform

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC04976K

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