4′-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading-Reference-Cited by-同舟云学术

4′-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading

Published:2019 Issue:62 Volume:55 Page:9112-9115
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Nawale Ganesh N.¹²³⁴⁵^ORCID,Bahadorikhalili Saeed¹²³⁴⁵,Sengupta Pallabi⁶⁷⁸⁹¹⁰,Kadekar Sandeep¹²³⁴⁵,Chatterjee Subhrangsu⁶⁷⁸⁹¹⁰,Varghese Oommen P.¹²³⁴⁵^ORCID

Affiliation:

1. Translational Chemical Biology Laboratory

2. Division of Polymer Chemistry

3. Department of Chemistry-Ångström

4. Uppsala University

5. Uppsala

6. Biomolecular NMR and Drug Design Laboratory

7. Department of Biophysics

8. Bose Institute

9. Kolkata

10. India

Abstract

We present synthesis, biochemical, biophysical and computational evaluation of 4′ gunanidino modified siRNA.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC04141A

Reference26 articles.

1. Delivery materials for siRNA therapeutics

2. RNAi

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

4. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

5. RNAi: The Nuts and Bolts of the RISC Machine

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in structural-guided modifications of siRNA;Bioorganic & Medicinal Chemistry;2024-08

2. 4′-C-Acetamidomethyl-2′-O-methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs;The Journal of Organic Chemistry;2024-02-23

3. Folate Receptor-Mediated siRNA Delivery: Recent Developments and Future Directions for RNAi Therapeutics;Nucleic Acid Therapeutics;2021-08-01

4. Beyond ribose and phosphate: Selected nucleic acid modifications for structure–function investigations and therapeutic applications;Beilstein Journal of Organic Chemistry;2021-04-28

5. Synthesis, Structural, and Conformational Analysis of 4′‐ C ‐Alkyl‐2′‐ O ‐Ethyl‐Uridine Modified Nucleosides;European Journal of Organic Chemistry;2021-01-28