Engineering a thermostable transketolase for arylated substrates-Reference-Cited by-同舟云学术

Engineering a thermostable transketolase for arylated substrates

Published:2017 Issue:2 Volume:19 Page:481-489
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Saravanan Thangavelu¹²³⁴,Reif Marie-Luise¹²³⁴,Yi Dong¹²³⁴,Lorillière Marion⁵⁶⁷⁸⁹,Charmantray Franck⁵⁶⁷⁸⁹,Hecquet Laurence⁵⁶⁷⁸⁹,Fessner Wolf-Dieter¹²³⁴

Affiliation:

1. Institut für Organische Chemie und Biochemie

2. Technische Universität Darmstadt

3. 64287 Darmstadt

4. Germany

5. Clermont Université

6. Université Blaise Pascal

7. Institut de Chimie de Clermont-Ferrand

8. BP10448

9. France

Abstract

Transketolase variants were engineered to utilize arylalkanals and benzaldehyde as substrates with up to 28-fold rate acceleration for C–C bond formation with good yields (50–73%) and virtually complete (3S)-stereoselectivity (>99% ee).

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/GC/C6GC02017H

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