The in silico identification of human bile salt export pump (ABCB11) inhibitors associated with cholestatic drug-induced liver injury
Author:
Affiliation:
1. Department of Pharmacy
2. The First Hospital of Lanzhou University
3. Lanzhou University
4. Lanzhou
5. China
6. Department of Science and Technology
7. College of Chemistry and Chemical Engineering
8. School of Pharmacy
Abstract
The RF and pharmacophore models can be considered as integrated screening tools to indicate the potential risk of cholestatic DILI.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2017/MB/C6MB00744A
Reference68 articles.
1. Drug-Induced Liver Disease
2. Drug-Related Hepatotoxicity
3. Drug-Induced Liver Injury
4. Preempting and preventing drug-induced liver injury
5. Int. J. Clin. Pharmacol., Ther. Toxicol., 1990, 28, 317322
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