Toxicological and anti-tumor effects of a linden extract (Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model

Author:

Ferreira Tiago12345ORCID,Nascimento-Gonçalves Elisabete12345,Macedo Sara12345ORCID,Borges Inês12345ORCID,Gama Adelina6745,M. Gil da Costa Rui12345ORCID,Neuparth Maria J.89105,Lanzarin Germano12345ORCID,Venâncio Carlos12345,Félix Luís12345,Gaivão Isabel11745,Alvarado Antonieta12345,Pires Maria J.12345,Bastos Margarida M. S. M.1213141516ORCID,Medeiros Rui171819205,Nogueira António212223245ORCID,Barros Lillian212223245ORCID,Ferreira Isabel C. F. R.212223245ORCID,Rosa Eduardo12345,Oliveira Paula A.12345ORCID

Affiliation:

1. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB)

2. Inov4Agro

3. University of Trás-os-Montes and Alto Douro (UTAD)

4. Vila Real

5. Portugal

6. Animal and Veterinary Research Centre (CECAV)

7. UTAD

8. CESPU

9. Institute of Research and Advanced Training in Health Sciences and Technologies

10. Gandra

11. Department of Genetic and Biotechnology and CECAV

12. LEPABE—Laboratory for Process Engineering

13. Environment

14. Biotechnology and Energy

15. Faculty of Engineering

16. University of Porto

17. Molecular Oncology and Viral Pathology Group

18. IPO-Porto Research Center (CI-IPOP)

19. Portuguese Institute of Oncology of Porto (IPO-Porto)

20. Porto

21. Centro de Investigação de Montanha (CIMO)

22. Instituto Politécnico de Bragança

23. Campus de Santa Apolónia

24. 5300-253 Bragança

Abstract

Study of the potential chemopreventive effects of T. platyphyllos Scop. extract against the development of HPV16-induced lesions and determination of its in vivo toxicity in HPV16-transgenic mice.

Funder

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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