Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
Author:
Affiliation:
1. Department of Chemistry and Biochemistry
2. The City College of New York
3. New York
4. USA
5. The Ph.D. Program in Chemistry
6. Laboratory of Virology and Chemotherapy
7. Rega Institute for Medical Research
8. 3000 Leuven
9. Belgium
Abstract
Amide group activation with BOP leads to facile modification at the C4 position of pyrimidine nucleosides.
Funder
National Center on Minority Health and Health Disparities
Division of Chemistry
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02334G
Reference54 articles.
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2. Thiation of Nucleosides. IV. The Synthesis of 5-Fluoro-2'-deoxycytidine and Related Compounds1,2
3. Stereospecific synthesis and biological evaluations of β-l-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine
4. Nucleosides. XVII. Pyrimidinyl Amino Acids1
5. Nucleosides. XLVII. Syntheses of some N4-substituted derivatives of 1-.beta.-D-arabinofuranosylcytosine and -5-fluorocytosine
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