Label-free technologies for target identification and validation-Reference-Cited by-同舟云学术

Label-free technologies for target identification and validation

Published:2016 Issue:5 Volume:7 Page:769-777
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Li Jing¹²³⁴,Xu Hua¹²³⁴,West Graham M.⁵⁶⁷⁴,Jones Lyn H.¹²³⁴

Affiliation:

1. Worldwide Medicinal Chemistry

2. Pfizer

3. Cambridge

4. USA

5. Structural Biology and Biophysics

6. Pfizer, Inc.

7. Groton

Abstract

Chemical probes have been instrumental in revealing new targets and confirming target engagement. However, substantial effort and resources are required to design and synthesize these probes. In contrast, label-free technologies have the advantage of bypassing the need for chemical probes. Here we highlight the recent developments in label-free methods and discuss the pros and cons of each approach.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00045B

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