Resolving hepatic fibrosis via suppressing oxidative stress and an inflammatory response using a novel hyaluronic acid modified nanocomplex-Reference-Cited by-同舟云学术

Resolving hepatic fibrosis via suppressing oxidative stress and an inflammatory response using a novel hyaluronic acid modified nanocomplex

Published:2021 Issue:24 Volume:9 Page:8259-8269
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Ren Lianjie¹²³,Li Jingjing¹²,Liu Lisha¹²,Wu Wantao¹²,Zhao Di¹²,Zhang Kai¹²,Xin Xiaofei¹²,Yang Lei¹²^ORCID,Yin Lifang¹²⁴⁵

Affiliation:

1. Jiangsu Province Engineering Research Center for R&D and Evaluation of Intelligent Drugs and Key Functional Excipients, China Pharmaceutical University, Nanjing 210009, China

2. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

3. Center for Drug Evaluation, NMPA, Beijing 100022, China

4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

5. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China

Abstract

A novel nanocomplex based on an oridonin conjugated hyaluronic acid polymer and LY294002 liposomes for resolving hepatic fibrosis via suppressing oxidative stress and an inflammatory response.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM01499D

Reference50 articles.

1. Hepatic inflammation and fibrosis: Functional links and key pathways

2. Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents

3. Progress in drug delivery system for fibrosis therapy