Redox double-switch cancer theranostics through Pt(<scp>iv</scp>) functionalised manganese dioxide nanostructures-Reference-Cited by-同舟云学术

Redox double-switch cancer theranostics through Pt(iv) functionalised manganese dioxide nanostructures

Published:2023 Issue:25 Volume:15 Page:10763-10775
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Brito Beatriz¹²³^ORCID,Ruggiero Maria Rosaria¹,Price Thomas W.¹,da Costa Silva Milene³^ORCID,Genicio Núria³,Wilson Annah J.¹,Tyurina Olga¹,Rosecker Veronika¹^ORCID,Eykyn Thomas R.¹^ORCID,Bañobre-López Manuel³^ORCID,Stasiuk Graeme J.¹^ORCID,Gallo Juan³^ORCID

Affiliation:

1. Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, Strand, WC2R 2LS London, UK

2. School of Life Sciences, Faculty of Health Sciences, University of Hull, Cottingham Road, HU6 7RX Hull, UK

3. Advanced Magnetic Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal

Abstract

A new redox-responsive double-switch cancer theranostic was developed based on Mn nanostructures and a Pt prodrug. The ability of these probes to respond to altered redox states was validated in 2/3D cell models and in a preclinical mouse model.

Funder

University of Hull

Wellcome

Engineering and Physical Sciences Research Council

European Regional Development Fund

Fundação para a Ciência e a Tecnologia

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR00076A

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