Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens-Reference-Cited by-同舟云学术

Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

Published:2018 Issue:22 Volume:16 Page:4076-4080
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yu Hai¹²³⁴⁵^ORCID,Santra Abhishek¹²³⁴⁵^ORCID,Li Yanhong¹²³⁴⁵^ORCID,McArthur John B.¹²³⁴⁵^ORCID,Ghosh Tamashree¹²³⁴⁵^ORCID,Yang Xiaoxiao¹²³⁴⁵^ORCID,Wang Peng G.⁶⁷⁸⁵^ORCID,Chen Xi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. University of California

3. One Shields Avenue

4. Davis

5. USA

6. Department of Chemistry and Center of Diagnostics & Therapeutics

7. Georgia State University

8. Atlanta

Abstract

Highly efficient streamlined total synthesis of complex prioritized gangliosides was achieved chemoenzymatically by sequential one-pot multienzyme (OPME) reactions with facile C18 cartridge purification schemes followed by high-yield acylation.

Funder

NIH Office of the Director

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01087K

Reference50 articles.

1. Glycosphingolipids in the Regulation of the Nervous System

2. Gangliosides of the Vertebrate Nervous System