Enamine-mediated Mannich reaction of cyclic <i>N</i>,<i>O</i>-acetals and amido acetals: the multigram synthesis of pyrrolidine alkaloid precursors-Reference-Cited by-同舟云学术

Enamine-mediated Mannich reaction of cyclic N,O-acetals and amido acetals: the multigram synthesis of pyrrolidine alkaloid precursors

Published:2022 Issue:35 Volume:20 Page:7105-7111
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Turmanov Rakhymzhan A.¹,Smolobochkin Andrey V.¹^ORCID,Gazizov Almir S.¹^ORCID,Rizbayeva Tanzilya S.¹^ORCID,Zapylkin Danil D.²,Voronina Julia K.³⁴^ORCID,Voloshina Alexandra D.¹,Syakaev Victor V.¹^ORCID,Kurenkov Alexey V.¹,Burilov Alexander R.¹,Pudovik Michail A.¹

Affiliation:

1. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, Russian Federation

2. Kazan National Research Technological University, 420015, K. Marksa str. 68, Kazan, Russian Federation

3. N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Ave. 31, 119991 Moscow, Russia

4. G.V. Plekhanov Russian University of Economics, Stremyanny Per. 36, 117997 Moscow, Russia

Abstract

An l-proline/Brønsted acid/base organocatalytic system enables gram-scale synthesis of 2-(acylmethylene)pyrrolidines through enamine activation.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01276F

Reference54 articles.

1. Pyrrolidine alkaloids and their promises in pharmacotherapy

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5. Syntheses of Hygrine and Cuscohygrine

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