A study on the AMACR catalysed elimination reaction and its application to inhibitor testing-Reference-Cited by-同舟云学术

A study on the AMACR catalysed elimination reaction and its application to inhibitor testing

Published:2016 Issue:2 Volume:14 Page:612-622
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yevglevskis Maksims¹²³⁴⁵,Lee Guat L.¹²³⁴⁵,Sun Jenny¹²³⁴⁵,Zhou Shiyi¹²³⁴⁵,Sun Xiaolong⁶³⁴⁵,Kociok-Köhn Gabriele⁶³⁴⁵,James Tony D.⁶³⁴⁵,Woodman Timothy J.¹²³⁴⁵,Lloyd Matthew D.¹²³⁴⁵

Affiliation:

1. Medicinal Chemistry

2. Department of Pharmacy & Pharmacology

3. University of Bath

4. Bath BA2 7AY

5. UK

6. Department of Chemistry

Abstract

The elimination of fluoride from 3-fluoro-2-methylacyl-CoA substrates by α-methylacyl-CoA racemase (AMACR 1A; P504S) was investigated as a method for determining enzyme activity and inhibitor potency.

Funder

University of Bath

Prostate Cancer UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB01541C

Reference57 articles.

1. Purification and Characterization of an alpha-Methylacyl-CoA Racemase from Human Liver

2. Purification and properties of an alpha-methylacyl-CoA racemase from rat liver