Is breaking of a hydrogen bond enough to lead to drug resistance?-Reference-Cited by-同舟云学术

Is breaking of a hydrogen bond enough to lead to drug resistance?

Published:2020 Issue:49 Volume:56 Page:6727-6730
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Dávila-Rodríguez María José¹²³⁴^ORCID,Freire Thales Souza¹⁵³⁴^ORCID,Lindahl Erik⁶⁷⁸⁹,Caracelli Ignez¹⁵³⁴^ORCID,Zukerman-Schpector Julio¹²³⁴^ORCID,Friedman Ran⁶⁷⁸⁹^ORCID

Affiliation:

1. Federal University of São Carlos

2. Department of Chemistry

3. São Carlos-SP

4. Brazil

5. Department of Physics

6. Linnæus University

7. Department of Chemistry and Biomedical Sciences

8. 391 82 Kalmar

9. Sweden

Abstract

Mutations lead to drug resistance by perturbing intra-molecular interactions, e.g. hydrogen bonds. Using the Abl/dasatinib complex as a model, resistance mutations were studied revealing subtle thermodynamic relations contributing to drug resistance.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Vetenskapsrådet

Cancerfonden

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC02164D

Reference23 articles.

1. Drug resistance in cancer: molecular evolution and compensatory proliferation

2. Insights on the alteration of functionality of a tyrosine kinase 2 variant: a molecular dynamics study

3. The catalytic activity of Abl1 single and compound mutations: Implications for the mechanism of drug resistance mutations in chronic myeloid leukaemia

4. The molecular mechanism behind resistance of the kinase FLT3 to the inhibitor quizartinib

5. Deciphering the molecular mechanism of FLT3 resistance mutations

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