A practical synthesis of chiral tricyclic cyclopenta[b]benzofuran, a key intermediate of Beraprost-Reference-Cited by-同舟云学术

A practical synthesis of chiral tricyclic cyclopenta[b]benzofuran, a key intermediate of Beraprost

Author:

Liu Xiaoyu¹²³⁴⁵,Tian Chengsen⁶⁷⁸⁹¹⁰,Jiao Xiaozhen¹²³⁴⁵,Li Xiaoyu¹²³⁴⁵,Yang Hongguang¹²³⁴⁵,Yao Yangyang¹²³⁴⁵,Xie Ping¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines

2. Institute of Materia Medica

3. Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation

4. Peking Union Medical College and Chinese Academy of Medical Sciences

5. Beijing 100050

6. Department of Medicinal Chemistry

7. Key Laboratory of Chemical Biology (MOE)

8. School of Pharmacy

9. Shandong University

10. Jinan

Abstract

A novel formal synthesis of Beraprost (1) is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference29 articles.

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