Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis-Reference-Cited by-同舟云学术

Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis

Published:2024 Issue:26 Volume:14 Page:18296-18310
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zahran Eman Maher¹^ORCID,Mohamad Soad A.²,Elsayed Mohamed M.³,Hisham Mohamed⁴,Maher Sherif A.⁵,Abdelmohsen Usama Ramadan¹⁶^ORCID,Elrehany Mahmoud⁷,Desoukey Samar Yehia⁶,Kamel Mohamed Salah⁶

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt

2. Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt

3. Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt

5. Department of Biochemistry, Faculty of Pharmacy, New Valley University, New Valley, Elkharga 71511, Egypt

6. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt

7. Department of Biochemistry, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City, 61111, Egypt

Abstract

Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02780A

Reference70 articles.

1. Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-κB/NLRP3 inflammasome pathway and ameliorates osteoarthritis

2. Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis

3. Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Radix Achyranthis Bidentatae on Osteoarthritis

4. Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

5. Scabicidal Potential of Coconut Seed Extract in Rabbits via Downregulating Inflammatory/Immune Cross Talk: A Comprehensive Phytochemical/GC-MS and In Silico Proof