New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells-Reference-Cited by-同舟云学术

New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells

Published:2021 Issue:5 Volume:12 Page:767-778
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Viktorsson Elvar Örn¹²³⁴⁵^ORCID,Aesoy Reidun⁶⁷⁸⁹⁵,Støa Sindre¹²³⁴⁵,Lekve Viola⁶⁷⁸⁹⁵^ORCID,Døskeland Stein Ove¹⁰⁸⁹⁵,Herfindal Lars⁶⁷⁸⁹⁵,Rongved Pål¹²³⁴⁵

Affiliation:

1. School of Pharmacy

2. Department of Pharmaceutical Chemistry

3. University of Oslo

4. N0316 Oslo

5. Norway

6. Centre for Pharmacy

7. Department of Clinical Science

8. University of Bergen

9. N-5021 Bergen

10. Department of Biomedicine

Abstract

Synthetic derivatives of the phenazine 5,10-dioxide natural antibiotics iodinin and myxin were shown to be potent and selective towards human leukemic cells.

Funder

Kreftforeningen

Norges Forskningsråd

Universitetet i Oslo

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00020A

Reference50 articles.

1. Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non‐Biofilm Cultures, and Mycobacterium tuberculosis