Energy landscape quantifications of histone H3.3 recognition by chaperone DAXX reveal an uncoupled binding specificity and affinity

Author:

Liu Fei12,Wang Jin23,Xu Rui-Ming45,Yang Na1ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Key Laboratory of Medical Data Analysis and Statistical Research of Tianjin, Nankai University, 300353 Tianjin, China

2. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China

3. Department of Chemistry and Physics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA

4. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

5. School of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

The landscape of uncoupled binding specificity and affinity in H3.3 recognition by DAXX.

Funder

National Natural Science Foundation of China

National Postdoctoral Program for Innovative Talents

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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