Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation-Reference-Cited by-同舟云学术

Metal ion mediated transition from random coil to β-sheet and aggregation of Bri2-23, a natural inhibitor of Aβ aggregation

Published:2015 Issue:3 Volume:7 Page:478-490
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Luczkowski Marek¹²³,De Ricco Riccardo⁴⁵,Stachura Monika⁶⁷⁸,Potocki Slawomir¹²³,Hemmingsen Lars⁶⁷⁸,Valensin Daniela⁴⁵

Affiliation:

1. Faculty of Chemistry

2. University of Wroclaw

3. 50-383 Wroclaw, Poland

4. Department of Biotechnology Chemistry and Pharmacy University of Siena

5. 53100 Siena, Italy

6. Department of Chemistry

7. University of Copenhagen

8. 2100 Copenhagen, Denmark

Abstract

Soft metal ion binding enforces critical rearrangement of the structure of Bri2-23, a natural inhibitor of Aβ aggregation, thus shifting its solution behavior to a self aggregating system.

Funder

Narodowe Centrum Nauki

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MT/C4MT00274A

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