X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors-Reference-Cited by-同舟云学术

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

Published:2015 Issue:33 Volume:51 Page:7108-7111
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ivanova Jekaterina¹²³,Leitans Janis⁴⁵³,Tanc Muhammet⁶⁷⁸⁹¹⁰,Kazaks Andris⁴⁵³,Zalubovskis Raivis¹²³,Supuran Claudiu T.⁶⁷⁸⁹¹⁰,Tars Kaspars⁴⁵³¹¹¹²

Affiliation:

1. Latvian Institute of Organic Synthesis

2. LV-1006 Riga

3. Latvia

4. Biomedical Research and Study Center

5. LV-1067 Riga

6. Università degli Studi di Firenze

7. NEUROFARBA Department

8. Section of Pharmaceutical Chemistry

9. 50019 Sesto Fiorentino

10. Italy

11. University of Latvia

12. Faculty of Biology

Abstract

The X-ray co-crystallization experiments of saccharin derivative with carbonic anhydrase revealed hydrolysis of isothiazole ring of saccharin and guided design of new inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC01854D

Reference25 articles.

1. Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste

2. Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

3. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

4. Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

5. Structure-based drug discovery of carbonic anhydrase inhibitors

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