A zuranolone nanocrystal formulation enables solubility-independent <i>in vivo</i> study of pentylenetetrazol-induced seizures in a rat model-Reference-Cited by-同舟云学术

A zuranolone nanocrystal formulation enables solubility-independent in vivo study of pentylenetetrazol-induced seizures in a rat model

Published:2024 Issue:1 Volume:1 Page:37-46
ISSN:2976-8713
Container-title:RSC Pharmaceutics
language:en
Short-container-title:RSC Pharm.

Author:

Chvíla Stanislav¹^ORCID,Kubová Hana²,Mareš Pavel²,Kudová Eva³,Štěpánek František¹^ORCID

Affiliation:

1. Department of Chemical Engineering, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic

2. Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic

3. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 542, 160 00 Prague 6, Czech Republic

Abstract

A phospholipid-stabilised nanocrystal suspension enables a solubility-independent formulation approach for preclinical evaluation of poorly soluble neuroactive steroids. The concept was presented in the evaluation of seizure severity in a rat model.

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

European Regional Development Fund

Ústav organické chemie a biochemie Akademie věd České republiky

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/PM/D3PM00043E

Reference59 articles.

1. NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

2. Neuroactive steroids: State of the art and new perspectives

3. Neuroactive steroids: Old players in a new game

4. Rapid effects of neurosteroids on neuronal plasticity and their physiological and pathological implications

5. THE 'ABC' OF GABA RECEPTORS: A BRIEF REVIEW

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