Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway

Author:

Li Hang1234,Lacey Alastair E.564,Shu Si1234,Kalaitzis John A.7894ORCID,Vuong Daniel564,Crombie Andrew564,Hu Jinyu1234,Gilchrist Cameron L. M.1234,Lacey Ernest56478,Piggott Andrew M.7894ORCID,Chooi Yit-Heng1234ORCID

Affiliation:

1. School of Molecular Sciences

2. The University of Western Australia

3. Perth

4. Australia

5. Microbial Screening Technologies Pty. Ltd.

6. Smithfield

7. Department of Molecular Sciences

8. Macquarie University

9. Sydney

Abstract

The hancockiamides are an unusual new family of N-cinnamoylated piperazines from the Australian soil fungus Aspergillus hancockii, originating from mixed nonribosomal peptide and phenylpropanoid pathways.

Funder

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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