Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Author:

Wang Daquan12345ORCID,Meng Lingjie12345ORCID,Fei Zhaofu6789,Hou Chen104511,Long Jiangang104511,Zeng Leli1213141516ORCID,Dyson Paul J.6789ORCID,Huang Peng1213141516ORCID

Affiliation:

1. School of Science

2. MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter

3. Instrumental Analysis Center

4. Xi'an Jiaotong University

5. Xi'an 710049

6. Institut des Sciences et Ingénierie Chimiques

7. Ecole Polytechnique Fédérale de Lausanne (EPFL)

8. 1015 Lausanne

9. Switzerland

10. School of Life Science and Technology; Ministry of Education Key Laboratory of Biomedical Information Engineering

11. China

12. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging

13. Laboratory of Evolutionary Theranostics

14. School of Biomedical Engineering

15. Health Science Center

16. Shenzhen University

Abstract

Multi-layered single-walled carbon nanotubes, termed SWNT@BSA@Au-S-PEG-FA@DOX, which integrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process.

Funder

National Natural Science Foundation of China

Program for New Century Excellent Talents in University

École Polytechnique Fédérale de Lausanne

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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