Organo-cation catalyzed enantioselective α-hydroxylation of pyridinone-fused lactones: asymmetric synthesis of SN-38 and irinotecan-Reference-Cited by-同舟云学术

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Organo-cation catalyzed enantioselective α-hydroxylation of pyridinone-fused lactones: asymmetric synthesis of SN-38 and irinotecan

Published:2024 Issue:73 Volume:60 Page:9954-9957
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Tian Jin-Rui¹,Qiao Yu-Hao¹,Zhuang Qing-Bo¹²,Fan Rong¹,Li Zhen¹,Zhang Xiao-Ming¹^ORCID,Zhang Fu-Min¹^ORCID,Tu Yong-Qiang¹^ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China

2. School of Pharmaceutical Sciences, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240, China

Abstract

A catalytic asymmetric α-hydroxylation of pyridinone-fused lactones has been developed, enabling the highly enantioselective formation of oxa-quaternary stereogenic centre of this tricyclic scaffold.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Science and Technology Department of Gansu Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC03580A

Reference101 articles.

1. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

2. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

3. Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site.

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