Facile synthesis of macrocyclic peptide toxins of GpTx-1 and its analogue-Reference-Cited by-同舟云学术

Facile synthesis of macrocyclic peptide toxins of GpTx-1 and its analogue

Published:2018 Issue:14 Volume:5 Page:2143-2147
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Chao¹²³⁴⁵^ORCID,Hong Mei¹²³⁴⁵^ORCID,Guo Xiaoqi⁶⁷⁸⁵⁹,Wu Fangming⁹¹⁰¹¹⁵,Tian Changlin⁶⁷⁸⁵⁹^ORCID,Wang Yangding¹²³⁴⁵,Xu Zhaoqing¹²¹³¹⁴¹⁵¹⁶^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Nano-Micro Materials Research

2. School of Chemical Biology & Biotechnology

3. Peking University Shenzhen Graduate School

4. Shenzhen 518055

5. China

6. School of Life Sciences

7. University of Science and Technology of China

8. Hefei 230027

9. High Magnetic Field Laboratory

10. Chinese Academy of Sciences

11. Hefei 230031

12. Key Laboratory of Preclinical Study for New Drugs of Gansu Province

13. School of Basic Medical Science

14. Lanzhou University

15. 199 West Donggang Road

16. Lanzhou 730000

Abstract

GpTx-1 and its analogue GpTx-71-1 were synthesized by a flexible and highly practical strategy via converging three segments based on C-terminal proline residues.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C8QO00415C

Reference38 articles.

1. Designing macrocyclic disulfide-rich peptides for biotechnological applications

2. Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics

3. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

4. Modulation of Ion Channels by Cysteine-Rich Peptides

5. Black mamba venom peptides target acid-sensing ion channels to abolish pain

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