A highly selective fluorescent probe for real-time imaging of bacterial NAT2 and high-throughput screening of natural inhibitors for tuberculosis therapy-Reference-Cited by-同舟云学术

A highly selective fluorescent probe for real-time imaging of bacterial NAT2 and high-throughput screening of natural inhibitors for tuberculosis therapy

Published:2019 Issue:1 Volume:3 Page:145-150
ISSN:2052-1537
Container-title:Materials Chemistry Frontiers
language:en
Short-container-title:Mater. Chem. Front.

Author:

Jin Yinzhu¹²³⁴⁵,Tian Zhenhao⁶⁷⁸⁵,Tian Xiangge¹²³⁴⁵,Feng Lei¹²³⁴⁵,Cui Jingnan⁶⁷⁸⁵,Ma Xiaochi¹²³⁴⁵^ORCID

Affiliation:

1. College of Pharmacy, Academy of Integrative Medicine

2. The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease

3. Dalian Medical University

4. Dalian 116044

5. China

6. State Key Laboratory of Fine Chemicals

7. Dalian University of Technology

8. Dalian 116024

Abstract

Fluorescent probeARHBis developed for detecting in various bacteria the activity ofN-acetyltransferase 2 (NAT2), a key enzyme in cell wall synthesis and widely considered to be a molecular target for anti-mycobacterial therapy.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QM/C8QM00514A

Reference35 articles.

1. Arylamine N-Acetyltransferases: Characterization of the Substrate Specificities and Molecular Interactions of Environmental Arylamines with Human NAT1 and NAT2

2. Role of acetyltransferases in the metabolism and carcinogenicity of aromatic amines

3. ArylamineN-Acetyltransferases: What We Learn from Genes and Genomes

4. Mapping AAC1 AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours

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