Analysis of physicochemical properties of protein–protein interaction modulators suggests stronger alignment with the “rule of five”-Reference-Cited by-同舟云学术

Analysis of physicochemical properties of protein–protein interaction modulators suggests stronger alignment with the “rule of five”

Published:2021 Issue:10 Volume:12 Page:1731-1749
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Truong Jia¹^ORCID,George Ashwin¹^ORCID,Holien Jessica K.¹^ORCID

Affiliation:

1. STEM College, RMIT University, Vic, Australia

Abstract

The physicochemical properties of protein–protein interaction (PPI) modulators vary between those on the market, those in clinical trials, and those in the early drug discovery pipeline.

Funder

Cancer Australia

Cure Cancer Australia Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00213A

Reference65 articles.

1. Diagnosing the decline in pharmaceutical R&D efficiency

2. Drugs Targeting Protein–Protein Interactions

3. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

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5. NetSig: network-based discovery from cancer genomes

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