TFPN-mediated racemization/epimerization-free amide and peptide bond formation-Reference-Cited by-同舟云学术

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TFPN-mediated racemization/epimerization-free amide and peptide bond formation

Published:2024 Issue: Volume: Page:
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Yang Jinhua¹^ORCID,Zhang Dou¹,Chang Yajing¹,Zhang Bo¹,Shen Peng¹,Han Chunyu¹^ORCID,Zhao Junfeng²^ORCID

Affiliation:

1. Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, P. R. China

2. Affiliated Cancer Hospital, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China

Abstract

A new electron-deficient aromatic-based coupling reagent, tetrafluorophthalonitrile (TFPN), designed according to the concept of dual coupling reagents, is developed to facilitate amide and peptide bond formation in a one-pot, two-step manner.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO01009D

Reference56 articles.

1. Peptide therapeutics: current status and future directions

2. A.Greenberg , C. M.Breneman and J. F.Liebman , The amide linkage: selected structural aspects in chemistry, biochemistry, and materials science , John Wiley & Sons , New York , 2000

3. Trends in peptide drug discovery

4. Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy

5. Biomimetic mineralization based on self-assembling peptides

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