A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles
Author:
Affiliation:
1. School of Pharmacy and Shanghai Key Laboratory of New Drug Design
2. East China University of Science and Technology
3. Shanghai 200237
4. P. R. China
Abstract
We have developed a copper/Ph-Phosferrox-catalyzed asymmetric Mannich reaction of Schiff bases with isatin-derived ketimines to prepare 3-substituted 3-aminooxindoles with excellent results.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/QO/C7QO00691H
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