A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles-Reference-Cited by-同舟云学术

A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles

Published:2018 Issue:1 Volume:5 Page:70-74
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhu Jing-Yan¹²³⁴,Yang Wu-Lin¹²³⁴,Liu Yang-Zi¹²³⁴,Shang Shao-Jing¹²³⁴,Deng Wei-Ping¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy and Shanghai Key Laboratory of New Drug Design

2. East China University of Science and Technology

3. Shanghai 200237

4. P. R. China

Abstract

We have developed a copper/Ph-Phosferrox-catalyzed asymmetric Mannich reaction of Schiff bases with isatin-derived ketimines to prepare 3-substituted 3-aminooxindoles with excellent results.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C7QO00691H

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4. Catalytic asymmetric direct Mannich reaction: a powerful tool for the synthesis of α,β-diamino acids

5. Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

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