Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis-Reference-Cited by-同舟云学术

Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis

Published:2021 Issue:9 Volume:57 Page:1097-1100
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Haoyang Wei-Wei¹²³⁴,Xiao Qi¹²³⁴,Ye Zhongju⁵⁶⁷⁴,Fu Yonghong¹²³⁴,Zhang Dan-Wei¹²³⁴^ORCID,Li Jian⁸⁹¹⁰⁴,Xiao Lehui⁵⁶⁷⁴,Li Zhan-Ting¹²³⁴^ORCID,Hou Jun-Li¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Fudan University

3. Shanghai 200433

4. China

5. State Key Laboratory of Medicinal Chemical Biology

6. Tianjin Key Laboratory of Biosensing and Molecular Recognition

7. College of Chemistry Nankai University

8. Clinical Laboratory Center

9. Children's Hospital of Fudan University

10. Shanghai 201102

Abstract

Unimolecular ion channel was constructed by attaching galactose moiety onto gramicidin A peptide, which exhibited liver cancer cell-targeting behavior. The channel-mediated ion flux could disturb ion homeostasis and induce apoptosis of the cells.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC08073J

Reference43 articles.

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3. High-resolution conformation of gramicidin A in a lipid bilayer by solid-state NMR

4. Gramicidin Channels

5. The Antimicrobial Activity of Gramicidin A Is Associated with Hydroxyl Radical Formation

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