A helix–coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family-Reference-Cited by-同舟云学术

A helix–coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family

Published:2015 Issue:5 Volume:44 Page:2370-2379
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Vazquez Diego S.¹²³⁴,Agudelo William A.¹²³⁴,Yone Angel¹²³⁴,Vizioli Nora¹²³⁴,Arán Martín⁵⁶⁴,González Flecha F. Luis¹²³⁴,González Lebrero Mariano C.¹²³⁴,Santos Javier¹²³⁴

Affiliation:

1. Instituto de Química y Físico – Química Biológicas

2. Universidad de Buenos Aires – CONICET

3. Buenos Aires

4. Argentina

5. Fundación Instituto Leloir and IIBBA – CONICET

6. 1405 Buenos Aires

Abstract

An iron-binding motif EExxED from the first α-helical stretch of frataxin was grafted on a foreign peptide scaffold:K_D= 1.9 ± 0.2 μM and 1 : 1 stoichiometry.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02796E

Reference58 articles.

1. Metals and neuroscience

2. The pathogenesis of Friedreich ataxia and the structure and function of frataxin

3. Aceruloplasminemia

4. Iron and iron management proteins in neurobiology

5. Iron and neurodegenerative disorders

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