A helix–coil transition induced by the metal ion interaction with a grafted iron-binding site of the CyaY protein family
Author:
Affiliation:
1. Instituto de Química y Físico – Química Biológicas
2. Universidad de Buenos Aires – CONICET
3. Buenos Aires
4. Argentina
5. Fundación Instituto Leloir and IIBBA – CONICET
6. 1405 Buenos Aires
Abstract
An iron-binding motif EExxED from the first α-helical stretch of frataxin was grafted on a foreign peptide scaffold:KD= 1.9 ± 0.2 μM and 1 : 1 stoichiometry.
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02796E
Reference58 articles.
1. Metals and neuroscience
2. The pathogenesis of Friedreich ataxia and the structure and function of frataxin
3. Aceruloplasminemia
4. Iron and iron management proteins in neurobiology
5. Iron and neurodegenerative disorders
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3. Conformational stability, dynamics and function of human frataxin: Tryptophan side chain interplay;Archives of Biochemistry and Biophysics;2022-01
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